This happened for me after upgrading Ubuntu 12.10 to Ubuntu 13.04.
This appears to be because there is a crash report and Ubuntu is not clearing it.
How to fix System program problem detected error
First you need to open a terminal session then run the following command:
sudo rm /var/crash/*
What that command does is remove all of the old crash reports.
If this does not fix the popup then you have a deeper problem and may need to investigate it further.
